Home > Books > Protein-Protein Complexes: Analysis, Modeling and Drug Design
Protein-Protein Complexes: Analysis, Modeling and Drug Design
View PDF

Protein-Protein Complexes: Analysis, Modeling and Drug Design

Publication Year: 2010
Edition: 1st
Authors/Editor: Zacharias, Martin
Publisher: World Scientific Publishing Co, Inc.
ISBN: 978-1-848-16338-6
  • Description
  • Details
  • Collections

Given the immense progress achieved in elucidating protein–protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field and this book does just that.

The text focuses on what can be learned about protein–protein interactions from the analysis of protein–protein complex structures and interfaces. What are the driving forces for protein–protein association? How can we extract the mechanism of specific recognition from studying protein–protein interfaces? How can this knowledge be used to predict and design protein–protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein–protein interactions, and how can we influence protein–protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?

The book consists of about 15 review chapters, written by experts, on the characterization of protein–protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein–protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein–protein complex structures (docking and homology modeling of complexes, etc.) and design of protein–protein interactions. It serves as a bridge between studying/analyzing protein–protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.

  • Platform:
    Ovid
  • Publisher: World Scientific Publishing Co, Inc.
  • Product Type: Book
  • Author/Editor: Zacharias, Martin
  • ISBN: 978-1-848-16338-6
  • Specialty:
    Biochemistry & Biophysics
  • Language: English
  • Edition: 1st
  • Pages: 400
  • Illustrations: 0
  • Year: 2010

Protein-Protein Complexes: Analysis, Modeling and Drug Design is included in the following Collections:

Free Instant Access
This Month

JOTM
Visible Body Human Anatomy Atlas This award-winning human anatomy general reference is a 3D visualization and learning tool used to interact with and explore the systems of the human body.
JOTM
PsycINFO® A comprehensive international bibliographic database, PsycINFO® provides access to more than 4 million citations in 29 languages.
JOTM
Journal of Orthopaedics for Physician Assistants The JBJS Journal of Orthopaedics for Physician Assistants is an academic resource that delivers ongoing orthopaedic education for physician assistants and nurse practitioners.
JOTM
Harvard Review of Psychiatry Founded by the Harvard Medical School’s Department of Psychiatry, this is the authoritative source for scholarly reviews and perspectives on important topics in psychiatry.

Noteworthy

Doody's Featured Books
Orthopaedic Basic Science: Foundations of Clinical Practice, 4th Edition
Concise and clinically relevant resource for the diagnosis and treatment of musculoskeletal diseases and conditions.

AAOS Comprehensive Orthopaedic Review, 2nd Edition
Offers sweeping coverage of core orthopaedic knowledge that spans the spectrum of the orthopaedic specialties.